ウサギ歯髄刺激疼痛に対するフェンタニルパッチ製剤の鎮痛作用
Jpn Pharmacol Ther 2001；29：849-854
| ウサギ歯髄刺激疼痛に対するフェンタニルパッチ製剤の鎮痛作用 Analgesic Action of Fentanyl Patch on the Tooth Pulp Stimulation Pain in Rabbits |
| 塩崎 静男1)、重岡 恒彦2)、鳥居 慎一2)、加藤 正巳3)、神谷 信一郎3)1)協和発酵工業株式会社 医薬総合研究所 2)ヤンセン協和株式会社 研究開発本部 3)株式会社日本バイオリサーチセンター 羽島研究所 |
| In this study we have investigated the analgesic action of the fentanyl patch on electroencephalogram （EEG） arousal response for tooth pulp stimulation pain in rabbits. The conscious animal was put into a testing box placed in a dark sound-proofed room, and the voltage threshold at which the EEG arousal response occurred was measured. Fentanyl patch （2.5 mg） caused a long-lasting （3 – 72 hours after application） increase in the voltage threshold, which was index of obvious analgesic effect. The rate of rise in the voltage threshold in the fentanyl patch group ranged from 154.2 to 204.2％ at 3 – 72 hours after application, which was significantly higher than the value before application. These results of present study suggested that the fentanyl patch might be especially useful for the chronic pain in the human patients. |